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KMID : 0613820140240020191
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Journal of Life Science
2014 Volume.24 No. 2 p.191 ~ p.195
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Single Dose Oral Toxicity of Schisandrae Semen Essential Oil in ICR Mice
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Han Min-Ho
Kim Joo-Wan
Kim Ki-Young
Kim Sung-Goo
Yu Gyeng-Jin
Cho Yong-Bok
Hwang Hye-Jin
Kim Byung-Woo
Kim Cheol-Min
Choi Yung-Hyun
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Abstract
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Essential oils extracted or purified from various plants have shown various beneficial effects. Seed parts of Schizandra chinensis Baillon (Schisandrae Semen) have been used as a traditional medicine for thousands of years in parts of Asia, including Korea, China, and Japan. However, the pharmacological mechanisms of essential oils purified from S. fructus (S. chinensis Baillon) remain largely unresolved. The aim of this study was to investigate the safety of Schisandrae Semen essential oil (SSeo) by a single- dose toxicity study in mice. SSeo was orally administered at a dose of 5,000 mg/kg in ICR mice. All animals were sacrificed after 14 days of treatment. After a single administration, mortality, clinical signs, body weight changes, and gross pathological findings were observed for 14 days. We also measured parameters of organ weight, clinical chemistry, and hematology. No toxicological change related to the test substance or mortality was observed after administration of a single oral dose of SSeo. There were no adverse effects on clinical signs, body weight, or organ weight and no gross pathological findings in any treatment group. The clinical chemistry and hematological parameters were within the normal ranges except total bilirubin. Therefore, the approximate lethal dose for oral administration of SSeo in mice was considered to be over 5,000 mg/kg. The results on the single-dose toxicity of SSeo indicate that it is not possible to reach oral dose levels related to death or dose levels with any harmful side effects.
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KEYWORD
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ICR mice, safety, Schisandrae Semen essential oil, single dose oral toxicity
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